Jan Booij
Molecular imaging, with special interest in neuropsychiatric disorders
Focus of research:
Our research is focused on neuroreceptor imaging with SPECT and PET, with special interests in Parkinson’s disease, dementia with Lewy bodies, schizophrenia, addiction, major depression, and neurotoxicity of XTC. In addiction, preclinial research is focussed on the development of new SPECT and PET tracers, and SPECT imaging in small laboratory animals.
AMC themes: Neurological & Psychiatric Disorders
Departments: Nuclear Medicine
Researchers:
Feasibility, mechanism of action and potential side effects of extended release depot naltrexone in opioid dependent patients
Phenylketonuria: dopamine transmission and relationship with phenylalanine levels and cognitive performance in adults – a pilot study
“Biological markers for psychiatric disorders in 22q11 copy number variation syndromes.”
Dopamine-serotonin dysbalans in dystonia
Clinical and neurobiological characterisation of “muscarinic receptor- deficit schizophrenia MRDS”
Effect of social exclusion on dopamine function in the human brain. A SPECT study in young adults with serious hearing impairment.
Post-delirium Cognitive Impairment
Key publications:
Visser I , Lavini C, Booij J, Reneman L, Majoie C, de Boer AGEM, Wekking EM, de Joode EA, Van der Laan G , van Dijk FJH, Schene AH, den Heeten GJ, Cerebral impairment in chronic solvent-induced encephalopathy. ANN NEUROL 2008;63 (5):572-580
McKeith I, O’Brien J, Walker Z, Tatsch K, Booij J, Darcourt J, Padovani A, Giubbini R, Bonuccelli U, Volterrani D, Holmes C, Kemp P, Tabet N, Meyer I, Reininger C, Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. LANCET NEUROL 2007;6 (4):305-313
Vastenhouw B, van der Have F, van der Linden AJA, von Oerthel L, Booij J, Burbach JPH, Smidt MP, Beekman FJ, Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT. MOL PSYCHIATR 2007;12 (11):984-987
de Win MML, Jager G, Booij J, Reneman L, Schilt T, Lavini C, Olabarriaga SD, den Heeten GJ, van den Brink W, Sustained effects of ecstasy on the human brain: a prospective neuroimaging study in novel users. BRAIN 2008;131 (Part 11):2936-2945
Ruhé HG , Booij J, Weert HCV, Reitsma JB, Fransen EJF, Michel MC, Schene AH, Evidence Why Paroxetine Dose Escalation is Not Effective in Major Depressive Disorder: A Randomized Controlled Trial With Assessment of Serotonin Transporter Occupancy. NEUROPSYCHOPHARMACOL 2009;34 (4):999-1010