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Guido van Wingen

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Neuroimaging in Psychiatry

Focus of research

The aims of my research are to understand the neural mechanisms underlying the development and treatment of psychiatric disorders, and to develop neuroimaging biomarkers for treatment response. I therefore investigate how biological and psychological factors that are associated with psychiatric vulnerability affect the brain, how successful treatment outcome can be predicted, and how it normalizes brain function. To address these questions, I use stress manipulations and various treatment approaches including neurostimulation (deep brain stimulation, electroconvulsive therapy), pharmacology (antidepressants), and psychotherapy, in combination with noninvasive neuroimaging techniques and machine learning methods.

AMC themes: Neurological & Psychiatric Disorders
Departments: Adult Psychiatry


Anouk van der Straten

“Predicting treatment outcome in obsessive-compulsive disorder using neuroimaging biomarkers”

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Arjan Schröder

Misophonia:an imaging study on the neurobiology and the efficacy of cognitive behavioural therapy

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Dominique Scheepens


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Filipa Raposo Pereira

“Imaging the effects of GHB-induced coma on the brain”

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Luka Liebrand

“Optimizing DBS in psychiatric patients: targeting of specific white matter bundles?”

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Michelle de Haan

“Fear-memory and individual differences in fear related processes”

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Nadine Eijsker

“Response inhibition in OCD and misophonia”

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Nina Levar

The Impact of Individual GABA variability on the Amygdala and Fear Learning

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Paul Zhutovsky

“Discovering neuroimaging biomarkers for the prediction of treatment outcome in PTSD.”

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Rajat Thomas

“Predicting treatment outcomes for psychiatric disorders”

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Key publications

Kaag AM, Levar N, Woutersen K, Homberg J, van den Brink W, Reneman L, van Wingen G, Hyperresponsiveness of the Neural Fear Network During Fear Conditioning and Extinction Learning in Male Cocaine Users. AM J PSYCHIAT 2016;173 (10):1033-1042

van Waarde JA, Scholte HS, van Oudheusden LJB, Verwey B, Denys D, van Wingen GA, A functional MRI marker may predict the outcome of electroconvulsive therapy in severe and treatment-resistant depression. MOL PSYCHIATR 2015;20 (5):609-614

Kroes MCW, Tendolkar I, van Wingen GA, van Waarde JA, Strange BA, Fernández G, An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans. NAT NEUROSCI 2014;17 (2):204-206

Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, Mantione M, Ooms P, de Koning P, Vulink N, Levar N, Droge L, van den Munckhof P, Schuurman PR, Nederveen A, van den Brink W, Mazaheri A, Vink M, Denys D, Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. NAT NEUROSCI 2013;16 (4):386-387

van Wingen GA, Geuze E, Caan MWA, Kozicz T, Olabarriaga SD, Denys D, Vermetten E, Fernández G, Persistent and reversible consequences of combat stress on the mesofrontal circuit and cognition. P NATL ACAD SCI USA 2012;109 (38):15508-15513


List of Publications

In the press (selection)





  • NPO De kennis van nu – Het bange brein


    Academic Medical Center, University of Amsterdam
    Department of Psychiatry, room PA3.128
    Meibergdreef 5
    1105 AZ Amsterdam
    The Netherlands

    Postal address:
    P.O. BOX 22660
    1100 DD Amsterdam
    The Netherlands

    Phone + 31 20 89 13523
    E-mail: (Enable Javascript to see the email address)