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Guido van Wingen
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Neuroimaging in Psychiatry
Focus of research
The aims of my research are to understand the neural mechanisms underlying the development and treatment of psychiatric disorders, and to develop neuroimaging biomarkers for treatment response. I therefore investigate how biological and psychological factors that are associated with psychiatric vulnerability affect the brain, how successful treatment outcome can be predicted, and how it normalizes brain function. To address these questions, I use stress manipulations and various treatment approaches including neurostimulation (deep brain stimulation, electroconvulsive therapy), pharmacology (antidepressants), and psychotherapy, in combination with noninvasive neuroimaging techniques and machine learning methods.
AMC themes: Neurological & Psychiatric Disorders
Departments: Adult Psychiatry
Researchers
Misophonia:an imaging study on the neurobiology and the efficacy of cognitive behavioural therapy
“Schema-ECT”
“Imaging the effects of GHB-induced coma on the brain”
“Optimizing DBS in psychiatric patients: targeting of specific white matter bundles?”
“Fear-memory and individual differences in fear related processes”
“Response inhibition in OCD and misophonia”
The Impact of Individual GABA variability on the Amygdala and Fear Learning
“Discovering neuroimaging biomarkers for the prediction of treatment outcome in PTSD.”![]()
“Predicting treatment outcomes for psychiatric disorders”
Key publications
Kaag AM, Levar N, Woutersen K, Homberg J, van den Brink W, Reneman L, van Wingen G, Hyperresponsiveness of the Neural Fear Network During Fear Conditioning and Extinction Learning in Male Cocaine Users. AM J PSYCHIAT 2016;173 (10):1033-1042
van Waarde JA, Scholte HS, van Oudheusden LJB, Verwey B, Denys D, van Wingen GA, A functional MRI marker may predict the outcome of electroconvulsive therapy in severe and treatment-resistant depression. MOL PSYCHIATR 2015;20 (5):609-614
Kroes MCW, Tendolkar I, van Wingen GA, van Waarde JA, Strange BA, Fernández G, An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans. NAT NEUROSCI 2014;17 (2):204-206
Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, Mantione M, Ooms P, de Koning P, Vulink N, Levar N, Droge L, van den Munckhof P, Schuurman PR, Nederveen A, van den Brink W, Mazaheri A, Vink M, Denys D, Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. NAT NEUROSCI 2013;16 (4):386-387
van Wingen GA, Geuze E, Caan MWA, Kozicz T, Olabarriaga SD, Denys D, Vermetten E, Fernández G, Persistent and reversible consequences of combat stress on the mesofrontal circuit and cognition. P NATL ACAD SCI USA 2012;109 (38):15508-15513
Publications
In the press (selection)
TV
- NOS Journaal – Hersenscan helpt te voorspellen of elektroshock helpt
- RTL Nieuws – Gerichtere behandeling depressie door hersenscan
- BBC News – Can we erase memories entirely?
- NTR – Pavlov met Marco Kroon
- MAX – BreinGeheim over angst
Radio
- NPO De kennis van nu – Het bange brein
Contact
Address:
Academic Medical Center, University of Amsterdam
Department of Psychiatry, room PA3.128
Meibergdreef 5
1105 AZ Amsterdam
The Netherlands
Postal address:
P.O. BOX 22660
1100 DD Amsterdam
The Netherlands
Phone + 31 20 89 13523
E-mail: (Enable Javascript to see the email address)